Search This Blog

Monday 30 June 2014

Erythrocyte Cell Membrane Proteins.

http://en.wikipedia.org/wiki/Red_blood_cell

The proteins of the membrane skeleton are responsible for the deformability, flexibility and durability of the red blood cell, enabling it to squeeze through capillaries less than half the diameter of the erythrocyte (7–8 μm) and recovering the discoid shape as soon as these cells stop receiving compressive forces, in a similar fashion to an object made of rubber.
There are currently more than 50 known membrane proteins, which can exist in a few hundred up to a million copies per erythrocyte. Approximately 25 of these membrane proteins carry the various blood group antigens, such as the A, B and Rh antigens, among many others. These membrane proteins can perform a wide diversity of functions, such as transporting ions and molecules across the red cell membrane, adhesion and interaction with other cells such as endothelial cells, as signaling receptors, as well as other currently unknown functions. The blood types of humans are due to variations in surfaceglycoproteins of erythrocytes. Disorders of the proteins in these membranes are associated with many disorders, such ashereditary spherocytosishereditary elliptocytosishereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria.

No comments:

Post a Comment