http://en.wikipedia.org/wiki/Erythropoiesis
As they mature, a number of erythrocyte characteristics change: The size of the cell is reduced and the cytoplasmic matrix increases in amount, and the staining reaction of the cytoplasm changes from blue to pinkish red because of the decrease in the amount of RNA and DNA. Initially, the nucleus is large in size and contains open chromatin. But as red blood cells mature the size of the nucleus decreases and finally disappears with the condensation of the chromatin material.
As they mature, a number of erythrocyte characteristics change: The size of the cell is reduced and the cytoplasmic matrix increases in amount, and the staining reaction of the cytoplasm changes from blue to pinkish red because of the decrease in the amount of RNA and DNA. Initially, the nucleus is large in size and contains open chromatin. But as red blood cells mature the size of the nucleus decreases and finally disappears with the condensation of the chromatin material.
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