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In addition, the micronuclear genes are interrupted by numerous "Internal Eliminated Sequences" (IESs). During development of the macronucleus, IESs are deleted and the remaining gene segments, Macronuclear Destined Sequences (MDSs), are spliced together to give the operational gene.Tetrahymena has about 6000 IESs and about 15% of micronuclear DNA is eliminated during this process. The process is guided by small RNAs and epigenetic chromatin marks.
In addition, the micronuclear genes are interrupted by numerous "Internal Eliminated Sequences" (IESs). During development of the macronucleus, IESs are deleted and the remaining gene segments, Macronuclear Destined Sequences (MDSs), are spliced together to give the operational gene.Tetrahymena has about 6000 IESs and about 15% of micronuclear DNA is eliminated during this process. The process is guided by small RNAs and epigenetic chromatin marks.
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