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Tuesday, 10 June 2014

Selenium.

http://en.wikipedia.org/wiki/Selenium
http://caloriecount.about.com/selenium-facts-nf317

Biological role


Selenium is a component of the unusual amino acids selenocysteine and selenomethionine
In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and certain forms of thioredoxin reductase found in animals and some plants (this enzyme occurs in all living organisms, but not all forms of it in plants require selenium).

Although it is toxic in large doses, selenium is an essential micronutrient for animals. In plants, it occurs as a bystander mineral, sometimes in toxic proportions in forage (some plants may accumulate selenium as a defense against being eaten by animals, but other plants such as locoweedrequire selenium, and their growth indicates the presence of selenium in soil).

The glutathione peroxidase family of enzymes (GSH-Px) catalyze certain reactions that remove reactive oxygen species such as hydrogen peroxide and organic hydroperoxides:
2 GSH + H2O2----GSH-Px → GSSG + 2 H2O
Selenium also plays a role in the functioning of the thyroid gland and in every cell that uses thyroid hormone, by participating as a cofactor for the three of the four known types of thyroid hormone deiodinases, which activate and then deactivate various thyroid hormones and their metabolites: the iodothyronine deiodinases are the subfamily of deiodinase enzymes that use selenium as the otherwise rare amino acid selenocysteine. (Only the deiodinase iodotyrosine deiodinase, which works on the last break-down products of thyroid hormone, does not use selenium).
Selenium may inhibit Hashimoto's disease, in which the body's own thyroid cells are attacked as alien. A reduction of 21% on TPO antibodies was reported with the dietary intake of 0.2 mg of selenium.
Increased dietary selenium intakes reduce the effects of mercury toxicity and it is now recognized that the molecular mechanism of mercury toxicity involves irreversible inhibition of selenoenzymes that are required to prevent and reverse oxidative damage in brain and endocrine tissues.

Selenium is an important trace mineral that works as an antioxidant, along with Vitamin E, to protect cells from damage from substances called free radicals. It also helps regulate the thyroid and is necessary for proper immune system function.

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