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Thursday, 17 July 2014

There are three main types of Professional Antigen-presenting Cells.

http://en.wikipedia.org/wiki/Antigen-presenting_cell

  • Dendritic cells (DCs), which have the broadest range of antigen presentation, and are probably the most important APC. Activated DCs are especially potent THcell activators because, as part of their composition, they express co-stimulatory molecules such as B7. This B7 co-stimulator of mature interdigitating dendritic cell (IDC) interacts with surface CD28 of naïve T-cell.
  • Macrophages, which are also CD4+ cells and are therefore susceptible to infection by HIV as well, since HIV invades immune cells through CD4+ receptor interactions.
  • Certain B-cells, which express (as B cell receptor) and secrete a specific antibody, can internalize the antigen, which bind to its BCR and present it incorporated to MHC II molecule, but are inefficient APC for most other antigens.
  • Certain activated epithelial cells.

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