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Saturday, 5 July 2014

Non-professional Phagocytes.

http://en.wikipedia.org/wiki/Phagocyte

Dying cells and foreign organisms are consumed by cells other than the "professional" phagocytes.These cells include epithelial cells, endothelial cells, fibroblasts, and mesenchymal cells. They are called non-professional phagocytes, to emphasize that, in contrast to professional phagocytes, phagocytosis is not their principal function.Fibroblasts, for example, which can phagocytose collagen in the process of remolding scars, will also make some attempt to ingest foreign particles.

Non-professional phagocytes are more limited than professional phagocytes in the type of particles they can take up. This is due to their lack of efficient phagocytic receptors, in particular opsonins—which are antibodies and complement attached to invaders by the immune system.Additionally, most nonprofessional phagocytes do not produce reactive oxygen-containing molecules in response to phagocytosis.

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