http://en.wikipedia.org/wiki/Macrophage
When a macrophage ingests a pathogen, the pathogen becomes trapped in a phagosome, which then fuses with a lysosome. Within the phagolysosome, enzymes and toxic peroxides digest the pathogen. However, some bacteria, such as Mycobacterium tuberculosis, have become resistant to these methods of digestion. Typhoidal Salmonellae too induce their own phagocytosis by host macrophages in vivo, and inhibit digestion by lysosomal action, thereby use macrophages to replicate and cause macrophage apoptosis. Macrophages can digest more than 100 bacteria before they finally die due to their own digestive compounds.
When a macrophage ingests a pathogen, the pathogen becomes trapped in a phagosome, which then fuses with a lysosome. Within the phagolysosome, enzymes and toxic peroxides digest the pathogen. However, some bacteria, such as Mycobacterium tuberculosis, have become resistant to these methods of digestion. Typhoidal Salmonellae too induce their own phagocytosis by host macrophages in vivo, and inhibit digestion by lysosomal action, thereby use macrophages to replicate and cause macrophage apoptosis. Macrophages can digest more than 100 bacteria before they finally die due to their own digestive compounds.
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