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Saturday, 19 July 2014

Leukotrienes are Chemotactic Ligands.

http://en.wikipedia.org/wiki/Chemotaxis

Leukotrienes belong to the group eicosanoids. They are significant lipid mediators of the arachidonic acid cascade converted by 5-lipoxigenase. Their predominant member is leukotriene B4 (LTB4), which elicits adhesion, chemotaxis, and aggregation of leukocytes. The characteristic chemoattractant effect of LTB4 is induced via G-protein-linked seven-transmembrane spanning leukotriene receptors, which are highly expressed in inflammation and allergy.

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