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Wednesday, 9 July 2014

Immunophenotyping of Basophils.

http://en.wikipedia.org/wiki/Basophil_granulocyte

Basophils of mice and humans have consistent immunophenotypes, including FcεRI+, CD123, CD49b(DX-5)+, CD69+, Thy-1.2+, 2B4+, CD11bdull, CD117(c-kit)–, CD24–, CD19–, CD80–, CD14–, CD23–, Ly49c–, CD122–, CD11c–, Gr-1–, NK1.1–, B220–, CD3–, γδTCR–, αβTCR–, α4 and β4-integrin negative.

Recently, Heneberg proposed that basophils may be defined as the cellular population positive for CD13, CD44, CD54, CD63, CD69, CD107a, CD123, CD164, CD193/ CCR3, CD203c, TLR-4, and FcεRI. When activated, some additional surface markers are known to be upregulated (CD13, CD107a, CD164), or surface-exposed (CD63, and the ectoenzyme CD203c).

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