In some cases a combined approach is the best Choice.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

Of course, in some cases a combined approach is the best choice. The main difficulty with implant surgery is to achieve a long lasting bulk that will not get absorbed over time. Sometimes a procedure has to be repeated several times to get a sustainable result. The most physiological location for an implant is the lateral wall of the nasal cavity, where the inferior turbinate used to project from. An easier location to implant is the septum, but it is less favorable as it is not the natural location of the turbinates and may over obstruct the airflow.

Surgical Treatment.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

Surgical treatment involves narrowing back the over enlarged nasal cavity—either by bulking up the partially resected turbinates with biological implant material (in cases where at least 50% of the inferior turbinate remain from anterior to posterior) or by creating neo-turbinates through submucosal implantation between the submucosa and bone in key locations in the nasal cavity.

Some other non surgical Treatment.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

Systemic medication as indicated for pain and or depression which is common (about 50%) in patients with this syndrome.
Sleeping with a cool mist humidifier.
Regular daily physical exercise and maintaining good general health to reduce the risk of deterioration of symptoms.

Non-surgical Treatment.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

Non-surgical treatment options are meant to maintain and improve the health of the remaining nasal mucosa in the ENS nose by keeping it moist and free of infection and irritation and by maintaining a good blood supply:
Keeping the nasal passages moist with saline-based mist sprays or gels.
Nasal irrigations of regular saline (Many patients prefer to use Ringer's Lactate solution with added xylitol instead, as they find it soothes the mucosa more than regular saline, and there are some empirical studies that back up that claim.
Irrigations of saline with 80 mg of gentimycin if ozena occurs.

Regenerative Medicine.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

There is hope among patients that with recent advances made in regenerative medicine otolaryngologists will begin to explore ways to use stem cells and tissue engineering technology to fully reconstruct the inferior turbinates of the nose and restore it back to normal. A clinical registry has been opened in 2014 to support future clinical trials in regenerative medicine specifically intended to treat patients with ENS.

Even surgical closure of the nostrils does not make the number of cilia increase again.

http://en.wikipedia.org/wiki/Empty_nose_syndrome


A study published in 2010 concluded that surgical reduction of the open cross-section of an 'empty nose' in order to positively influence aerodynamics and to increase airway-resistance does not, however, alter the conditioning function of the nose, which is irreversibly damaged.Another study reported that when ciliated cells have been lost because of degeneration of the nasal mucosa, even surgical closure of the nostrils does not make the number of cilia increase again.

There have been several reports of attempts to reconstruct the inferior Turbinates.

http://en.wikipedia.org/wiki/Empty_nose_syndrome

In recent years there have been several reports of attempts to reconstruct the inferior turbinates of the nose through submucusal implantation of various implant materials, in an attempt to restore normal nasal aerodynamics and physiology. The sample of patients reported on was very small and the follow-up was relatively short, but the results showed some promise.